Glycine
Amino acid taken before bed, often 2-3g, to help sleep onset
Sweet-tasting amino acid, around 2-3 grams in the evening. Small trials report faster sleep onset and better next-day alertness, possibly via a drop in core body temperature. Inexpensive, well tolerated, and so an add-on to sleep stacks rather than the centerpiece.
Who backs it
Sorted by strength of stance
- Andrew HubermanDoes it
Neuroscientist · Huberman Lab
Two grams of glycine goes into the evening list on three or four nights a week rather than every night.
Source: Huberman Lab: Toolkit for Sleep - Bryan JohnsonDoes it
Founder · Blueprint longevity protocol
1,200mg of glycine arrives in the morning Longevity Mix rather than as an evening sleep supplement.
Source: Blueprint: Longevity Mix
Aimed at the same thing
Other entries filed under sleep.
- Supplement$$$Cheap: Roughly under $50, or under $15/month.
Magnesium (threonate or glycinate)
Taken 30-60 minutes before bed to help with sleep onset
Backed by 11 of 44 stacks: 8 do it, 1 recommend it, 2 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Melatonin
Widely sold as a sleeping aid; mostly a timing signal, not a sedative
Backed by 4 of 44 stacks: 0 do it, 1 recommend it, 3 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Ashwagandha
Adaptogen used short-term to lower cortisol during stressful stretches
Backed by 2 of 44 stacks: 1 do it, 1 recommend it, 0 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
L-theanine
Amino acid from tea used for calm focus, or with caffeine
Backed by 2 of 44 stacks: 2 do it, 0 recommend it, 0 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Apigenin
Chamomile-derived compound taken before bed, usually 50mg
Backed by 1 of 44 stacks: 1 do it, 0 recommend it, 0 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Myo-inositol
Taken before bed, often for getting back to sleep after waking
Backed by 1 of 44 stacks: 1 do it, 0 recommend it, 0 have discussed it
Supplement entry · notes paraphrased from cited sources, quoted excerpts copied from the transcript they link to. Not medical advice. Not affiliated with, endorsed by, or reviewed by anyone listed. How this works.