Myo-inositol
Taken before bed, often for getting back to sleep after waking
Around 900mg of a sugar alcohol in the evening, added to sleep stacks mainly by people whose problem is waking at 3am rather than falling asleep. It also has a separate literature in PCOS and anxiety at much higher doses. Evidence for the sleep use specifically is limited and largely anecdotal.
Who backs it
Sorted by strength of stance
- Andrew HubermanDoes it
Neuroscientist · Huberman Lab
Myo-inositol at 900mg targets getting back to sleep after waking in the night rather than falling asleep in the first place.
Source: Huberman Lab: Your Top Questions on Sleep, Answered
Aimed at the same thing
Other entries filed under sleep.
- Supplement$$$Cheap: Roughly under $50, or under $15/month.
Magnesium (threonate or glycinate)
Taken 30-60 minutes before bed to help with sleep onset
Backed by 11 of 44 stacks: 8 do it, 1 recommend it, 2 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Melatonin
Widely sold as a sleeping aid; mostly a timing signal, not a sedative
Backed by 4 of 44 stacks: 0 do it, 1 recommend it, 3 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Ashwagandha
Adaptogen used short-term to lower cortisol during stressful stretches
Backed by 2 of 44 stacks: 1 do it, 1 recommend it, 0 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Glycine
Amino acid taken before bed, often 2-3g, to help sleep onset
Backed by 2 of 44 stacks: 2 do it, 0 recommend it, 0 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
L-theanine
Amino acid from tea used for calm focus, or with caffeine
Backed by 2 of 44 stacks: 2 do it, 0 recommend it, 0 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Apigenin
Chamomile-derived compound taken before bed, usually 50mg
Backed by 1 of 44 stacks: 1 do it, 0 recommend it, 0 have discussed it
Supplement entry · notes paraphrased from cited sources, quoted excerpts copied from the transcript they link to. Not medical advice. Not affiliated with, endorsed by, or reviewed by anyone listed. How this works.