Sulforaphane (broccoli sprouts)
Compound from broccoli sprouts that switches on the NRF2 pathway
Chewing or chopping cruciferous vegetables forms it, most concentrated in broccoli sprouts, and it activates the NRF2 antioxidant response pathway. Home-grown sprouts are the cheapest reliable source; supplement products vary because the enzyme needed to form it is fragile. Interest centers on detoxification enzymes and inflammatory markers.
People on record
Sorted by strength of stance
Does it: documented as part of their own routine. Recommends: explicitly advises other people to do it. Discusses: covered it substantively without clear personal adoption; this can include criticism or disagreement.
- Bryan JohnsonDoes it
Founder · Blueprint longevity protocol
Broccoli seed extract in the capsules and 250g of broccoli in his fixed vegetable dish supply sulforaphane precursors daily.
Source: Blueprint: Essentials capsules - Mark HymanDoes it
Physician · The Dr. Hyman Show · author of Young Forever
Takes a broccoli-extract product for its sulforaphane content as part of the longevity stack he lists, the experimental tier he says he does not expect everybody to follow.
Source: The Doctor's Farmacy: My Personal Longevity Routine - Rhonda PatrickDoes it
Biomedical scientist · FoundMyFitness
At least two tablets of sulforaphane a day for NRF2 activation, and she has covered broccoli sprout preparation in detail.
Source: FoundMyFitness: her top five supplements“But also if you’re living in a polluted place — I tell all my friends in L.A., I am like, you have to be taking sulforaphane. It’s just like a non-negotiable, right?”
The Tim Ferriss Show #819 transcript (opens in a new tab) · 26 Jul 2025
Aimed at the same thing
Other entries filed under longevity.
- Supplement$$$Cheap: Roughly under $50, or under $15/month.
Protein powder
Whey or plant protein used to hit a daily protein target
On record from 18 of 62 tracked people: 13 do it, 3 recommend it, 2 have discussed it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Omega-3 (EPA/DHA)
Fish or algae oil, often 1-2g EPA daily
On record from 9 of 62 tracked people: 8 do it, 1 recommends it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Multivitamin
Daily multivitamin and mineral taken as a nutritional backstop
On record from 6 of 62 tracked people: 5 do it, 1 recommends it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Vitamin D3
Daily D3 through the darker months, usually paired with K2
On record from 6 of 62 tracked people: 5 do it, 1 recommends it - Supplement$$$Mid: Roughly $50 to $500, or up to $50/month.
NMN and NAD precursors
Nicotinamide mononucleotide or riboside, taken to raise NAD+
On record from 4 of 62 tracked people: 3 do it, 1 has discussed it - Supplement$$$Mid: Roughly $50 to $500, or up to $50/month.
AG1 (Athletic Greens)
Powdered greens and vitamin blend taken as a morning drink
On record from 3 of 62 tracked people: 3 do it
Supplement entry · notes paraphrased from cited sources, quoted excerpts copied from the transcript they link to. Not medical advice. Not affiliated with, endorsed by, or reviewed by anyone listed. How this works.