NMN and NAD precursors
Nicotinamide mononucleotide or riboside, taken to raise NAD+
Cellular NAD+ declines with age, and it is central to energy metabolism and DNA repair. These supplements are intended to raise it. Trials so far show that blood NAD+ can be raised; whether that produces any meaningful clinical benefit in humans is still an open question. It is one of the more expensive bets in the longevity stack, and it is best described as unproven rather than disproven.
People on record
Sorted by strength of stance
Does it: documented as part of their own routine. Recommends: explicitly advises other people to do it. Discusses: covered it substantively without clear personal adoption; this can include criticism or disagreement.
- Bryan JohnsonDoes it
Founder · Blueprint longevity protocol
NR at 450mg or NMN at 500mg goes in daily as an NAD precursor, and he is clear that the human evidence for a clinical benefit is not there yet.
Source: Blueprint: Bryan Johnson's protocol Biohacker · Bulletproof Coffee
Qualia NAD+, a blend of three NAD precursors with resveratrol, sits in what he calls his longevity stack. He frames declining NAD as one of seven core aging processes and says the same page is a starting point, not his full regimen.
Source: Dave Asprey blog: 7 reasons you're aging faster than you should be- Mark HymanDoes it
Physician · The Dr. Hyman Show · author of Young Forever
Sits in what he calls his longevity stack, taken daily. He says the stack is a lot and does not expect everybody to copy it, and human evidence for NMN remains thin.
Source: The Doctor's Farmacy: My Personal Longevity Routine - Rhonda PatrickDiscusses
Biomedical scientist · FoundMyFitness
Covered the NAD+ literature in depth and stays measured about it, separating raised blood NAD+ from any demonstrated clinical benefit.
Source: FoundMyFitness: nicotinamide mononucleotide topic page
Aimed at the same thing
Other entries filed under longevity or energy.
- Supplement$$$Cheap: Roughly under $50, or under $15/month.
Multivitamin
Daily multivitamin and mineral taken as a nutritional backstop
On record from 6 of 62 tracked people: 5 do it, 1 recommends it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Vitamin D3
Daily D3 through the darker months, usually paired with K2
On record from 6 of 62 tracked people: 5 do it, 1 recommends it - Supplement$$$Mid: Roughly $50 to $500, or up to $50/month.
AG1 (Athletic Greens)
Powdered greens and vitamin blend taken as a morning drink
On record from 3 of 62 tracked people: 3 do it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Vitamin B12
The supplement plant-based stacks here treat as non-negotiable
On record from 2 of 62 tracked people: 1 does it, 1 recommends it - Supplement$$$Expensive: Several hundred dollars and up.
Bioniq personalized supplements
One daily granule formula built from your blood test results, adjusted over time
On record from 1 of 62 tracked people: 1 does it - Supplement$$$Cheap: Roughly under $50, or under $15/month.
Prebiotic fiber supplement
A daily fiber powder to top up what the diet misses
On record from 1 of 62 tracked people: 1 does it
Supplement entry · notes paraphrased from cited sources, quoted excerpts copied from the transcript they link to. Not medical advice. Not affiliated with, endorsed by, or reviewed by anyone listed. How this works.